| dc.description.abstract | There has been increasing resistance of Gram negative bacteria causing UTI to several
antibiotics over years around the globe and has complicated management of UTI especially in
under developed World. Study was carried out at Lancet Laboratories to assess the antibiotic
resistance patterns so that effective antibiotics are identified especially for empirical
management of UTI.
A cross sectional study was conducted on a total of 200 urine samples received at Lancet
Laboratories Buganda Road from February to May 2015 to determine antimicrobial resistance
pattern on Gram Negative bacteria. Mid-stream Urine was received and Cultured using standard
Microbiology procedures, sensitivity was done using Kirby Bauer method.
The overall prevalence of Gram Negative bacteria that caused UTI were at30.5 %( 61/200),E.
coli as the most prevalent with (80.3%: 49/61) followed by Proteus mirabilis (4/61, 6.71%),
Serratia Species (3/61:4.9%), Raoultella ornithinolytica (2/61:3.2%), KlebsiellaPneumoniae
(2/61:3.3%) and Kluyvera Species (1/61:1.6%).ESBL had a prevalence of 44.3% out of the 61 E.
Coli were ESBL producer at a rate of 85.45% followed by Serratia species(7.2%), Proteus
Mirabilis(3.7%) and Klebsiella pneumoniae (3.7%).ESBL producing organism are more
responsible to the production of XDR compared to MDR, XDR were noted more prevalent with
42.6% more than MDR (13.1 %.). Fosfomycin, Ertapenem, Meropenem, and Imipenemwere the
most effective antibioticsfollowed by Amikacin and Nitrofurantoin, the least effective
were Ampicillin
and
Cephazolin. | en_US |
