Browsing by Author "Kyakulaga, Philip"

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    Establishment Of Hematological Reference Ranges For Pregnant Women Attending Antenatal Care At Nakaseke Hospital
    (International Health Sciences University, 2018-11) Kyakulaga, Philip
    Background: Measurement of haematological parameters is key to the diagnosis, treatment and monitoring of many infectious diseases and pregnancy related conditions. However, less effort has been put in establishment of these parameters in developing countries where clinical care strongly relies on laboratory diagnosis. This study reports on the haematological reference ranges among pregnant attending antenatal care in Nakaseke Hospital. Methods: A cross sectional study was conducted during the months of August and November, 2018 among pregnant women attending antenatal care in Nakaseke hospital. Ethylene di-amine tetra acetic acid (EDTA) venous blood were collected and a full blood count (FBC) was run. Data was presented in tabular form as mean ± SD in reference to 95 % reference intervals. Results: Overall, 135 consented pregnant women were enrolled. The red blood cells (RBCs) showed a gradual decrease in haemoglobin and RBCs counts as the pregnancy progressed from 1 st to 2nd and then became constant 3rd trimester as 4.04-5.02, 3.77-4.67 and3.92- 4.7 respectively. The haematocrit value decreases from the1st to the 2nd trimesters and then remains constant in the 3rd trimester as 36.94- 45.3, 34.67-41.35 and 32.47-44.79 respectively. There was no significant change in MCV. For the white blood cells (WBCs), there was no significant change in the total count from the 1 st to the 2nd trimesters, but there is significant rise in the 3 rd trimester as 4.57-8.75 , 4.41-8.85 and 4.8-9.2 respectively. The granulocytes were affected by the increase in numbers. The total platelet count decreased from the 1 st to the 2nd to the 3 rd trimesters as 152.38-267.24, 145.41-224.59 and 128.48-220.94 respectively. Conclusion: This study has explored a variance in the blood cell parameters across the different gestational stages. To this, gestation- and age-based reference values for haematological parameters are key to their clinical care and management.
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    Haematological Parameters of Pregnant Women Attending Antenatal Care at Nakaseke Hospital, Central Uganda
    (cient periodique, 2018-12-03) Kyakulaga, Philip; Mwambi, Bashir; Atuhairwe, Christine; Taremwa, Ivan Mugisha
    Introduction Establishment of haematological ranges is key to laboratory diagnoses and management of pregnancy-related complications. The parameters to a large extent ought to be population-based, never the less, there are limited studies on the reference ranges of pregnant women for the local population. This study reports on the haematological parameters of pregnant women attending antenatal care at Nakaseke Hospital, central Uganda. Materials and Methods A cross-sectional study involving pregnant women was conducted from the month of May to August 2018. Ethylene diamine tetraacetic acid (EDTA) venous blood samples were collected and a full blood count (FBC) was run. Data for the haematological parameters was presented in tabular form as mean ± SD in reference to 95% reference intervals. Results One hundred and thirty-five adult (18 years, and above) consented pregnant women were enrolled. The red blood cells (RBCs) counts and haemoglobin concentration showed a gradual decrease during the first two trimesters and a slight increase during the third trimester. There was no significant change in MCV. The white blood cells (WBCs) did not show a significant change in the total count from the first to the second trimesters, and there was a significant rise during the third trimester. The granulocytes were affected by the increase in numbers. Platelet count decreased during the first to the third trimesters. Conclusion This study has explored a variance in the haematological parameters. This necessitates incorporation of specific reference ranges for clinical care and management of gestational disorders.